CELIAC DISEASE OR GLUTEN ENTEROPHYSIS
“In case of complaints and illnesses that you cannot explain the reason, please have CELIAC in mind”
Dr. Ceyhun NURİ
It is an intestinal disease characterized by destruction of structures called villus, which plays a role in food absorption especially in the upper small intestines in people who are susceptible to genetic infrastructure against proteins found in cereals such as wheat, rye, barley, oats, and gluten.
Approximately 10,000 years ago, consumption of meat, vegetables, and fruits decreased gradually as people increased consumption of cereals, milk and processed products, along with the built-in pasture of hunting, gathering and nomadic life. This disease, which seems to be a rare event, has begun to grow dramatically with the globalization and the reach of the food, seeds from different race and geographical regions to every part of the world, and serious food mismatch (Food Intolerance) against nutrients all over the world. People start to feed on their temperaments. People start to feed against their temperaments. In some culturally or tribally living communities that are still isolated, (some tribes of Africa, East China, Pacific Islands, South East Asia, Japan)celiac is a very rare disease.
Celiac Disease is the leading cause of malabsorption seen in children. It is more common in women than in men. The frequency of first degree relatives and single eggs (Monozygotic) twins is ten times higher. Because of the underlying immune system irregularity, the rate of other autoimmune diseases (Addison, Sjögren, Thyroiditis, Type I DM, Osteoporosis, Primer Biliary Cirrhosis, Down syndrome, Selective IgA deficiency etc.) is high.
Classic View of Formation Mechanism
This disease, which can manifest itself at any age, is known to be an autoimmune reaction. In other words, the immune system elements in the small intestine mucus are destroying the physiological structures (villus etc.) due to the excessive reaction against the intestinal cells. But it is not known why this autoimmune reaction occurs.
Dr. Ceyhun NURI’s View of Formation Mechanism:
In the results of the research published in CELL RESEARCH on September 20, 2011, it is explained as follows: Every food consumed, every plant that is eaten, has micro RNAs of that plant and they reach the tissues together with the circulation after they are absorbed from the intestines. These microRNAs begin to interfere with the genes of the individual. In a study by Zhang and his friends, they found that rice and wheat, carrying MIR156a microRNAs, boosted human LDL cholesterol. So, as we have mentioned above, if we take the globalization, the western type and the malicious reverse nutrition into account, it is possible to reach the following result. It is not right to look at food only in terms of proteins, fats, carbohydrates and calories. We should not lose sight of which genetic information they carry us. In this case, the proteins and enzymes that are encoded and synthesized by DNA that starts to change start to deteriorate. When the protein is degraded, the metabolism begins to change as the enzyme reacts to the other reactive side. And the wrong encoding (Mutation) in this DNA begins to be transmitted from the generation to the generation. Although it is thought that many genetic disorders play a role in the development of celiac disease, the main responsible structure is DQ2ve DQ8. It is also thought that they play a role in the onset and course of celiac disease with viruses (Adenovirus type 12, type 7, Rubella, Human Herpesvirus 1, Hepatitis C, and HIV) with very high degree of amino acid sequence similarity with gliadin.
Environmental factors play a very important role in the development of the disease. It leads to the deterioration of the intestinal protection shield (Probiotic bacteria, Intestinal sealing wall) rich in fermented products (yoghurt, kefir, etc.), refined flour and sugary foods. The immune system (IgE, Leukocyte, NK, Leukotriene, ANA, etc.) reacts excessively to increased allergens and toxins when the excessive foreign matter entering the body is not cleared by the liver.
For digestion, several enzymes (Lactase, Protease, Lipase, Maltase, Peptidase, etc.) should be secreted from many organs such as stomach, intestine, liver, gall bladder, and pancreas. But, as you can see, due to the wrong genetic information, these enzymes are either not secreted or are produced with different qualities (enzymes that take an active role in the metabolism of gluten and similar proteins). In this case, a portion of undigested food particles (amino acids) begin to accumulate in the intestines. They begin to form a dead layer and plugs on the intestinal surface. This results in the movement of some centers where the elements of the immune system, such as bone marrow, lymph nodes, are produced. As a result, a dense autoimmune, inflammatory response to the intestinal surface begins to develop. Humoral and cytotoxic cellular immune responses are developed against gliadin (especially its 33-mer peptide) in glutenin, predominantly IgA, more weakly IgG. (“Human leukocyte antigen” (HLA) class IL, HLA-DQ2, DQ8, Th1 / Th0 CD4 + Gluten-sensitive T cells). So, the body opens the war against the intestinal surface. In this battle, villus atrophy, crypt hyperplasia and small intestinal surface result in catastrophic damage. An increase in immature epithelial cells is observed on the intestinal surface due to this process. Although destruction mostly affects the proximal, that is, the beginning part of the small intestine, distal (lower) parts are also affected. As a result, body nutrients cannot be absorbed, body loss starts, frequent diarrhea occur. As the absorption decreases, weight, height losses will appear, as the absorption of calcium deteriorates, bone disorders will start.
Symptoms and signs of celiac disease may be quite variable. Most complaints and findings are related to impaired proximal intestinal absorption. The most common symptom is frequent, abundant, oily, light colored, foul-smelling, dull-looking stool.
Symptoms often start to appear in infants after the first six months with additional food, especially cereals. They typically come with complaints of gastrointestinal system such as height-weight deficiency, frequent nausea, juvenile stools, chronic diarrhea, anorexia, unexplained weight loss, abdominal distension, reflux, and malabsorption.
Although it seems like an illness in which the intestinal problems are frontal, the intestinal symptoms and signs are very common in these patients because all the absorption and breakthrough processes are affected.
In these patients, musculoskeletal symptoms such as rickets, osteoporosis, dental enamel spoilage, shortness of stature, arthralgia (pain in joints), and myopathy can be seen due to impairment of calcium and vitamin D metabolism.
Hematologic symptoms such as anemia (anemia), leukopenia, thrombocytopenia due to impaired absorption of iron, folate, B12, VE, and K vitamins in the stomach and intestine may occur.
Neuropsychiatric symptoms such as epilepsy, peripheral neuropathy, depression, dementia, schizophrenia, impairment of perception, headache, cerebellar ataxia, attention deficit are the complaints of the gastrointestinal system in celiac disease.
Complaints related to skin and mucous membranes such as mouth apthas, dermatitis herpetiformis can be seen.
Celiac Disease can come from under the complaints of delayed puberty, menstrual irregularities, recurrent abortion, infertility, elevated liver enzymes, chronic hepatitis, chronic fatigue, hair loss, intestinal lymphoma, thyroiditis and many more.
This list of indications may be extended further. But let’s briefly say that. We have given names to these signs / findings so that we can understand and negotiate. If the body functions like absorption, metabolism, production, detoxification, cleansing ability, circulation, respiration, neural communication, oscillation etc. are impaired, we will have more complaints than we can count.
Although it is a very common disease in our society, most people do not know that their complaints depend on this disease. If the patients suffer from loss of appetite, height, swelling, chronic diarrhea, chronic constipation, recurrent abdominal pain or vomiting, hypoplasia of teeth minerals, unexplained shortness, delayed puberty, refractory iron deficiency anemia, osteoporosis, and frequent illness etc., the first disease that should come to mind is celiac. And serologic screening tests must be performed in these patients.
Serologic screening tests should also be performed in first-degree relatives of patients diagnosed with celiac disease, autoimmune thyroiditis, Type I DM, Down / Williams / Turner syndrome, selective IgA deficiency and other autoimmune diseases.
The diagnosis is made by findings such as lymphocyte (IEL) increase, crypt hyperplasia, villus atrophy, intestinal mucosal flattening in the epithelial mucosal epithelium of the intestine, which is actually detected in the biopsy of IB. However, making the easier serological tests before this invasive procedure is considered the first step in diagnosis today.
Serological tests are the most valuable methods for screening purposes. In these serological tests 1) the proteins in the food (gluten). 2) Trying to detect antibodies against the structural proteins (endomyosin, reticulin, transglutaminase) in the intestinal mucosa.
Serological tests used for screening (in IgA, IgG construct):
Antigliadin antibody (AGA)
Serological tests used in the diagnosis and follow-up of the disease (in Iga structure):
- Anti-Tissue Transglutaminase Antibody (Anti-TG)
- Anti-endomicin antibody (EMA)
- Anti-reticulin antibody (ARA)
- It would not be right to look at the Ig structure of the antibody under 2 years of age and situations with IgA deficiency (may give false negative results). In these cases, it would be more accurate to look at the antibodies in the IgG construct.
- In today’s conditions, if we consider the techniques, cost, and reliability of these tests, our approach to testing will be more accurate:
- Anti-tissue transglutaminase antibody (Anti-dTG) for screening
- Anti- endomysium antibody (EMA) to support diagnosis of celiac disease in suspicious cases
- Antigliadin antibody (AGA) under 2 years of age
- Anti-dTG IgG, AGA IgG in selective IgA deficiency with
It is still seen as a golden approach in the diagnosis of celiac disease. In all cases where anti-dTG and / or EMA positive is detected, small intestine biopsy should be performed to confirm the diagnosis of celiac disease.
Diagnosis and follow-up of celiac disease is absolutely necessary in other hematological, biochemical, radiological examinations:
|– Whole Blood Count
-Iron, Ferritin, Iron
– Zinc, Zinc binding
-Insulin (Hunger), Hunger- blood sugar
-CRP, RF, ES Speed
– Calcium, Phosphorus
– Liver enzymes
-Total protein, albumin
– microscopic inspection of stool
-PTH, vitamin D
-IgA, IgG, IgM
|-Thyroid function tests
– Thyroid antibodies (TG, Anti Tg, Anti TPO)
— Autoantibodies (ANA, dsDNA, AMA, ASMA, LKM 1)
– Cranial MR
– Tissue group
Classical Treatment Approach
There is no treatment for celiac disease.
The general belief is that this reaction against gluten is persistent in the body, so it insists on the application of lifelong gluten-free diet.
Dr. Ceyhun NURİ’s Treatment Approach:
There is ABSOLUTELY a Treatment for Celiac Disease!!!
No one has to be convicted of lifelong gluten-free speech if you solve the causes and connections of the autoimmune response.
As we mentioned earlier, the most important point is to correct the genetic background. And there are plants and seeds that will regulate it and turn the body back to its main balanced order (HOMEOSTAZIS).
It is imperative that the elements that are determined to be deficient in treatment are conducted. Many other substances that are absolutely important contributors to cell repair such as vitamin B12, folic acid, zinc, calcium, vitamin D, which are very important in the neurological structure, help to transport oxygen to the cell, must be quickly compensated.
It is useful to point out that we need to meet the deficit by taking minerals, elements, proteins, vitamins, which we really need from our natural sources like meat, vegetables, fruit, and sun. But it is not possible for us to take advantage of these natural sources until treatment and order are established in humans, such as celiac disease, that lacks absorption, ingestion, digestion, and production of intestinal enzymes.
COMPLICATIONS THAT CAN BE DEVELOPED IF NOT TREATED
In patients who have not been diagnosed and treated for a long time, many autoimmune diseases that may develop due to the same immune background can be added to the clinic. Aging, Osteoporosis, Ulcerative jejunoileitis, T-cell intestinal lymphoma, Anemia, Rickets, Hepatitis, Cerebral cirrhosis, Epilepsy, Osteoporosis in the elderly, Ulcerative jejunoileitis, T-cell intestinal lymphoma, Anemia, Rickets, Hepatitis, Brain cirrhosis, Epilepsy, Cerebellar ataxia, Neuropathy It is possible to encounter many conditions such as Myocarditis, Cardiomyopathy, Kidney problems, Adrenal insufficiency, Infertility, Depression, Resistant obesity and many more. Neuropathy, Myocarditis, Cardiomyopathy, Kidney problems, Adrenal insufficiency, Infertility, Depression, Resistant obesity and many more.
If treatment is delayed, other nutrients that digest here will begin to be affected, secondary to damage to the epithelium on the surface of the intestine. The production of lactase enzyme, which plays a role in the digestion of milk and dairy products, will deteriorate and nutrition will eventually deteriorate. A similar situation is seen in the digestion of carbohydrates, sugars and other nutritional ingredients (sucrose, maltase, etc.)
RECOMMENDATIONS TO DR.CEYHUN NURI:
– Gluten-free diet must be strictly applied until the patient’s background is resolved. Rice and corn for these patients are considered safe grain foods because they do not contain toxic prolamin.
-It has been shown in many studies that long-term delivery of the baby’s milk to the baby and initiation of simultaneous appetizers after 6 months protects against celiac disease and many other diseases. We find it useful to breastfeed until the age of two.
– It is better to avoid milk, fruit and fruit juices in the first weeks until the surface of the gut is regenerated (repaired). (Disaccharides secondary to the destruction of the intestinal epithelium, due to lack of lactase enzyme)
– To help repair the intestinal mucosa, three times a day on an empty stomach a sweet spoon of pure corn oil consumption will make a positive contribution to the process.
– It will be very useful to increase the consumption of products supporting the biological life of the bowel and the intestines (home-made yoghurt, kefir, fig, date, garlic, etc.)
– You should consume 2-3 cups of plantago tea a day, which is useful for repairing the rough surface structure.
Dr. Ceyhun NURİ
For more information, please contact us at our contact details.
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