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ASTHMA TREATMENT

ASTHMA

DEFINITION

It is characterized by chronic inflammation in the airways and characterized by seizure-like cough, dyspnea, and sensation of pressure, and generally reversible airway obstruction, which manifests itself with complaints such as wheezing.

Asthma attack is a process that is accompanied by deterioration of breathing functions such as shortness of breath, tightness in the chest, wheezing and breathing, as well as deterioration of respiratory functions in the asthmatic patient.

EPIDEMIOLOGY

Careful examination of human and medical history shows that genetic and chronic diseases are increasing as infectious diseases decrease. When we look at the world as a whole, the asthma rate of 11-15% in 70-80 years has reached 22-35% (Canada, USA, Britain, Ireland, Australia). It is also seen more frequently in children than in adults in Turkey.

However, when we look at underdeveloped countries, asthma cases have been found at around 3.6% in a survey conducted in the Jimma city of Ethiopia, and in rural areas, scarcely asthma cases were found.

As a result, very rare diseases such as asthma, hashimoto, cardiovascular disease have been rising like avalanche about a hundred years ago. BUT WHY!!!

ETIOLOGY / RISK FACTORS

• Low water consumption

 

• Smoking

 

• House dust

 

• Pets

 

• Moldy environment

 

• Cockroaches

 

• Job

 

• Air pollution

 

• Allergen

 

• Gastroesophageal Reflux

• Can be triggered by exercise

•Genetic predisposition

 

• Having Family Asthma Story

 

• Atopia

 

• Psychological factor

 

• Food additives

 

• Cleaning materials

 

• Cosmetics

 

• Room spray

 

• Obesity

 

• Medicines

• Weather change

 

PATHOPHYSIOLOGY

Classical Approach:

Definite Reason is not determined

In general, in people who are susceptible to the respiratory tract, breathlessness develops for a certain period of time with environmental effects together with the edema of the bronchial surface mucosa.

Dr. Ceyhun NURI’s View of Formation Mechanism:

  Asthma is a chronic inflammatory disease that results from the deterioration of the intestinal natural flora.

When looking at the anatomy and physiology of the respiratory system, the airways remind the branches of the tree and at the end of these branches there are vesicles called round alveoli which are fruitful. These alveoli are covered with thin capillary vessels over them. The oxygen support needed for the continuation of life takes place in these capillaries, Oxygen (O2) is being taken Carbon dioxide (CO2) is being removed.

Of course during the exchange, together with oxygen, some harmful substances that the airway secretions cannot stop and clean (Chemicals, allergens, toxins, cosmetic chemicals, viruses, harmful bacteria, etc.) also reaches the alveolar wall. These harmful substances, which normally must be thrown away, cannot be thrown away due to some operational errors and stick to the dried alveolar. These substances are mostly destroyed by the immune system elements. However, if the exposure is continuous, the immune system will begin to exhibit a tendency to react continuously. And chronic / inflammatory environment will begin to occur.

Surfactant, which is composed of cholesterol, phospholipid, LDL, HDL and protein, which allows the alveolar sacs to remain open, is actually a body secretion that starts to be produced in the human body in the near term of birth, and when this substance is missing, alveoli is closed and air intake, O2 / CO2 change cannot occur. The surfactant also play a role in the defense of these vesicles. Like all body secretions, this substance also needs some conditions to be secreted and show correct metabolic consequences. It is possible to summarize these conditions in the following way.

Firstly, it is the amount of water in the contents of the fluids that provide fluidity. As the amount of water decreases, the liquids become dense (stone formation in the kidneys, blood clotting, bile stones, etc.). If we think the alveoli are like apples hanging on the tip of a branch, Alveoli also collapse as they lose their surface fluid like the apple wrinkles when it loses its water. In addition, cigarette smoking, blockage of the pulmonary arteries (vessels that provide blood circulation in the respiratory system), some occupational exposures (Painter, Miner, etc.) rapidly reduce the level of Surfactant. Mechanisms that regulate the structure, secretion and functioning of this material work according to the genetic program of those cells (DNA, RNA). Every food we take affects our genetic makeup. The quality of the water we drink, the additives in the food, the refining of the food. The new genetic codes that are taken by the body with food cause the DNA of the cells to change. When DNA changes, the protein produced, the enzymes start to change. As the protein changes, the metabolic responses change as the enzyme changes. For example, microRNA carried by refined rice causes both the structure and the amount of circulating LDL cholesterol to change. Since the LDL cholesterol in the structure of the alveoli in our alveolar cutter is bound to 90% circulating LDL, its structure also starts to change. As a result, the cavities in which the air change is experienced begin to close, becomes deficient against the harmful gases, bacteria and viruses.

If we look at other formation mechanisms:

Despite the increasing pharmaceutical industry, asthma is rapidly increasing as it is not decreasing. While industrialized countries show an avalanche of growth, the incidence in developing countries remains limited. What has changed in the last century so that this increase is seen? These differences among countries suggest that the main causes of asthma development are environmental changes. In the last fifty years, especially with the globalization of the world, environmental factors have begun to be destroyed, especially by losing their naturalness. When we take a look at our changing diet, we see that food like our ancestors’ butter, breast milk, house yogurt, kefir, fresh vegetables / fruits, vitamin D (sun exposure), rock salt, have gone out; frozen foods, hormone-fed chickens, refined products, candies, refined salt has taken their place. Mostly cesarean births with an increase of 80% took the place of normal births.

These cesarean births, the frequent use of antibiotics, nutritional errors leading to loss of intestinal flora (ready, mixed, additive foods, undigested foods), cigarettes, acid drinks, D vitamins deficiency, gluten, heavy metals, reduced water consumption lead to loss of intestinal flora followed by impairment of the immunity (Th2 / Th1 ratio varies in the direction of Th2) which is effective on the intestinal surface. In the end the intestinal protection wall disappears. In the study of an animal, mice that first met with antigen (toxin) in their lives if their intestinal biologically viable life envelope (probiotic bacteria) is defective respiratory problems are observed, while in healthy, intestinal microflora, there is no respiratory distress.

When this intestinal sealing wall breaks down, rapid and intense foreign algae and harmful amino acid particles begin to enter our bodies. The liver and defense (immune) system is rapidly activated to eliminate these allergens and toxins. When this exposure is continuous, activation in the immune system begins to turn into unnecessary overreaction. And the autoimmune response starts (the normal response against the entering amino acids starts to build up against the amino acids in our own production). Inflammation gets out of control.

Let’s see the inflammation in my asthma a little closer. Let’s see a little closer to the inflammation in Hashimoto. Normally, when the baby is in the mother’s womb (intrauterine period), Th2 cells are the important items of the fetal immune system, the formation of the natural physiological intestinal cover after birth leads to a balance between Th2 / Th1, which starts with Th2 formation. However, the inflammatory process is triggered when the increase of Th2 is repeated due to the human error. Th2 activates macrophage and NK (IFN-gamma, TNF-alpha, IL2 release). Th1, on the other hand, activates the immune system such as IgE, basophil, eosinophil, mast cells (IL4, IL5, IL9, and IL13). As a result, they increase the production of a number of inflammatory substances (Group II Prostaglandins, Group IV Leukotriene).

Asthma is the result of such a long-lasting inflammatory process. As a result, the alveolar sacs that need to be filled with air are filled with inflammatory fluid and begin to swell (edema). The person enters the process of drowning in the inflammation he produces with his own hand and desire. Just like your skin, the cell that is decreasing in water begins to deteriorate to dryness like cracking in the soil. In such a cell, the Ph balance shifts in the direction of acid from 7,35-7,45. The water-dependent ion pores are closed. The passage of some substances that need to go in and out is stopped (Na, K, Ca, Metabolic residues). Osmosis stops and the cell dies. Neurological activity begins to release neurotransmitters in the direction of immunostimulation to remove this dead cell population. The immune system is stimulated (Leukotriene, NK, Th, Lymphocyte, Histamine, etc.). As a result, SINCE YOU DO NOT DRINK WATER, the cell dies, the brain gives the wrong command, and the immune system begins to attack right and left, unnecessary inflammation increases. And the process of many diseases begin.

DIAGNOSIS

The first rule in diagnosis approach is the detailed questioning of the patient (anamnesis) and the realization of the physical examination without any details being missed. In anamnesis, chest pressure sensation, wheezing may be diagnosed by detecting the absence of symptoms such as coughing spasms. Patient statements may vary at different times of the day, at different seasons of the year.

Symptoms of Asthma (Symptoms):

• Shortness of breath

 

• Cough Seizures

 

• chest tightness

 

• Whistling Respiration

 

• The repeater of symptoms

• Symptoms are seen at night or in the morning

Symptoms may heal spontaneously or may require support

 

• Presence of triggering factors

 

• Cyanosis

• Increased palpitation / heart rate

 

Tests with diagnostic value are diagnostic supports after diagnosis.

  • Respiratory Function Tests
  • Lung Graphy

DIFFERENTIAL DIAGNOSIS

Diseases that can be confused with asthma

• COPD

 

• Obliterative Bronchiolitis

 

• Bronchiectasis

 

• Cystic Fibrosis

• Chronic rhinosinusitis

• Cough with ACE Blockers

 

• Left Heart Failure

 

• Reactive Airway Dysfunction Syndrome

• Gastroesophageal Reflux

 

TREATMENT

Classical Treatment Approach

THERE IS NO TREATMENT TO END THE DISEASE!!!

Expectation from treatment: Maintaining normal daily life by preventing symptoms.

Drugs used for this purpose:

• Corticosteroid

• Beta-2 agonists

• Theophylline

• Leukotriene receptor antagonists

• Anti IgE

• Anticholinergics

 

NOTE: The whole Treatment Approach is based on the suppression of the physiological processes of the immune system and the body.

Dr. Ceyhun NURİ’s Treatment Approach:

THE DISEASE WILL COMPLETELY BE FINISHED!!!

The first rule is that the body reactions will not be suppressed. Reason for overreaction is to be corrected. (Prevention of excessive stimulation of Auxiliary Th2 cells is one of the main targets in therapy. In addition, anti-inflammatory agents (IL-10, TGF-Beta) secreted by regulatory T cells reduce the inflammatory process and stop the allergic response by causing suppression of adjuvant Th2 cells.

Things to be done for this purpose.

  1. The feeding pattern that increases the flame should quickly be avoided.
  2. A program to help organize the bowel and liver system should be started.
  3. The identified deficiencies will be resolved (D Vit, Iron, B Vit, etc.)
  4. Treatment of systems and genetic information flow will be started (tototherapeutic prescriptions)
  5. The body’s allergen and toxin load will be reduce (Cupping, Ozone application etc.)

 

We can gather our treatment target in the following way:

  1. Detoxification of the body, eventually the body (cleansing)
  2. System Regeneration (Repair)

III. Providing Genetic Information Flow (DNA Repair)

 

  1. THE ADVISORY OF CEYHUN NURI:

 

  • Black tea consumption should be reduced. Excess consumption of three glasses a day may exacerbate complaints.
  • Omega 3 (Fish Oil). Patients with complaints of chronic inflammatory disease provide daily consumption as the sum of EPA + DHA is 2.5-3 gr.
  • Normal breeding should be given priority to revitalize the intestinal flora. Child breastfeeding must be maintained until the age of 2 years.
  • Probiotic nutrition should be given weight (yogurt, kefir). Alpha-1 Antitrypsin pulls down the Tumor Necrosis Factor levels and helps suppress inflammation in the bowel. The secretariat increases IgA production and increases intestinal surface defense. In addition, probiotics reduce the formation of antigen-stimulating antigens because they contribute to protein digestion in the intestine with some enzymes (proteases) that they secrete.
  • Turmeric was very effective in preventing asthma attacks. We recommend twice daily 1-2 teaspoon in ground form.
  • The grape kernel containing the so-called resveratrol substance, (Corticosteroid) more effectively acts in asthma patients positively than dexamethasone. We recommend 1-2 sweet spoon a day.
  • Nuts must be consumed. Magnesium inside helps relax the muscles in the airways (Bronchospasm).
  • Increase consumption of olive oil. Vitamin E in it helps to resolve the airway spasm (bronchospasm) by normalizing the body’s defense response (inhibiting IgE uptake and leukotrienes)

 

Advices to be given are too much to fit into this article.

 

Dr. Ceyhun NURİ

For more information, please contact us at our contact details.

 

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